鉤端螺旋體IgM免疫熒光試劑盒

Leptospira IgM IFA Kit

廣州健侖生物科技有限公司

主要用途：用于檢測(cè)人血清中的鉤端螺旋體IgM抗體

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鉤端螺旋體IgM免疫熒光試劑盒

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【公司名稱】 廣州健侖生物科技有限公司
【】    楊永漢 
【】 
【騰訊 】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-3室
【企業(yè)文化】

另一個(gè)還不清楚的問(wèn)題是，單層的視網(wǎng)膜上皮到底是怎么演變成視杯形狀的。總的來(lái)說(shuō)，機(jī)械力和組織的剛性控制著上皮組織的形變。通過(guò)在體外測(cè)定視杯形成過(guò)程中上皮不同部分的受力方向和組織剛性，我們發(fā)現(xiàn)，形成這一結(jié)構(gòu)需要三個(gè)步驟。在這一過(guò)程中，視網(wǎng)膜的剛性減弱，柔韌性增加;同時(shí)，視網(wǎng)膜與上皮交界處的細(xì)胞變成楔形;zui后，視網(wǎng)膜因快速擴(kuò)展而內(nèi)陷。這三個(gè)步驟對(duì)視杯的形成至關(guān)重要。實(shí)際上，當(dāng)我們把這些與組織的機(jī)械性質(zhì)有關(guān)的條件輸入計(jì)算機(jī)模擬程序后，的確出現(xiàn)了我們熟悉的酒杯形狀。
在培養(yǎng)皿中，誘導(dǎo)胚胎干細(xì)胞形成視網(wǎng)膜的過(guò)程，扼要地再現(xiàn)了胚胎中眼睛發(fā)育的主要步驟。這項(xiàng)技術(shù)對(duì)基礎(chǔ)研究的價(jià)值不可估量，同時(shí)有助于開(kāi)發(fā)一些療法，幫助視力減退的患者恢復(fù)視力。如下圖所示，在加入名為生長(zhǎng)因子的分子之后，胚胎干細(xì)胞開(kāi)始聚集;大約5天后，開(kāi)始形成zui原始的視泡。及至第7天，視泡向外凸出;幾天后，該結(jié)構(gòu)內(nèi)陷，形成視杯;到第24天，視網(wǎng)膜的所有層次初具雛形。
應(yīng)用前景
聽(tīng)說(shuō)我們的研究后，人們自然想知道，用小鼠胚胎干細(xì)胞所做的工作究竟能否給眼疾患者帶來(lái)好處。在這個(gè)方向上，我們已取得了一些進(jìn)展。值得一提的是，我的實(shí)驗(yàn)室zui近剛剛在一篇文章中報(bào)道過(guò)，我們成功地使人類(lèi)胚胎干細(xì)胞分化成視杯和多層神經(jīng)組織。我們預(yù)計(jì)，同樣的培養(yǎng)方法也可應(yīng)用于人類(lèi)的誘導(dǎo)多能干細(xì)胞(induced pluripotent stem cells，iPS)——成熟細(xì)胞受到特定刺激后，經(jīng)過(guò)逆轉(zhuǎn)的發(fā)育過(guò)程，可成為誘導(dǎo)多能干細(xì)胞，其行為與胚胎干細(xì)胞相似。我們還發(fā)明了更好的低溫貯存方法，能在液氮中儲(chǔ)存由人類(lèi)胚胎細(xì)胞分化成的視網(wǎng)膜組織。
這些工作都將推動(dòng)體外培養(yǎng)的視網(wǎng)膜組織應(yīng)用于醫(yī)學(xué)。例如，我們可以制造人工視網(wǎng)膜，幫助人們研究常見(jiàn)眼部疾病的病理機(jī)制，推動(dòng)新藥和基因療法的研究，逆轉(zhuǎn)視網(wǎng)膜病變。
*有數(shù)百萬(wàn)人患有黃斑變性、視網(wǎng)膜色素變性(retinitis pigmentosa)和青光眼(glaucoma)，這三種視網(wǎng)膜退行性疾病的患者也許都可以從我們的研究中獲益。三種疾病中，發(fā)生病變的視網(wǎng)膜細(xì)胞層各不相同。在黃斑變性中，由于支撐組織“崩潰”，視網(wǎng)膜上皮的完整性受到影響，光感受器細(xì)胞也發(fā)生退化，尤其是視網(wǎng)膜中心區(qū)域。在視網(wǎng)膜色素變性中，視桿細(xì)胞(rod，光感受器細(xì)胞的一種)數(shù)量一年年逐漸減少，zui初也是zui常見(jiàn)的癥狀是“夜盲”，而后來(lái)，患者會(huì)喪失大部分視野，只剩下一小塊中心視野。在青光眼病例中，受損的則是神經(jīng)節(jié)細(xì)胞，這類(lèi)細(xì)胞會(huì)伸出視神經(jīng)，把視網(wǎng)膜與大腦后部皮層上的視覺(jué)處理中心連接起來(lái)。

Another issue that remains unclear is how the monolayer of the retinal epithelium evolves into a cup-like shape. In general, mechanical and tissue rigidity control epithelial tissue deformation. By measuring the direction of stress and the stiffness of the tissue in different parts of the epithelium in vitro during the formation of the optic cup, we found that three steps are required to form this structure. During this process, the rigidities of the retina weaken and the flexibility increases. At the same time, the cells at the junction of the retina and the epithelium become wedges. Finally, the retina is invaded by rapid expansion. These three steps on the formation of the cup is crucial. In fact, when we put these conditions related to the mechanical properties of the organization into our computer simulation program, we were indeed familiar with the shape of the glass.
The process of inducing embryonic stem cells to form the retina in petri dishes briefly reproduces the major steps in eye development in the embryo. The technology is invaluable to basic research and helps to develop therapies that help patients with vision loss regain their eyesight. As shown in the figure below, embryonic stem cells began to aggregate after the addition of a molecule called growth factor; about five days later, the most primitive vesicles began to form. By day 7, the vesicles bulged outward; a few days later, the structure retracted to form an optic cup; by day 24, all layers of the retina were initially rudimentary.
Application prospects
After hearing about our research, it is natural to wonder whether the work done with mouse embryonic stem cells can benefit patients with eye diseases. In this direction, we have made some progress. It is worth mentioning that my laboratory recently reported in an article that we successfully differentiated human embryonic stem cells into optic cups and multiple layers of neural tissue. We expect that the same culture can also be applied to human induced pluripotent stem cells (iPS), which are induced pluripotent stem cells after their specific stimuli have undergone a specific process of development Embryonic stem cells are similar. We have also invented better cryogenic storage methods that store retinal tissue differentiated from human embryonic cells in liquid nitrogen.
These efforts will promote the use of cultured retinal tissue in medicine. For example, we can make artificial retina to help people study the pathological mechanism of common eye diseases, promote the research of new drugs and gene therapy, and reverse the retinopathy.
Millions of people worldwide have macular degeneration, retinitis pigmentosa and glaucoma, and all three patients with retinal degenerative diseases may benefit from our study. Of the three diseases, retinal layers of the lesion vary. In macular degeneration, the integrity of the retinal epithelium is affected by the collapsing of the supporting tissue, and the photoreceptor cells also degenerate, especially in the central retinal region. In retinitis pigmentosa, the number of rods (a type of photoreceptor cells) gradually decreases year by year, the first and most common symptom is "night blindness", and later, the patient will lose most of the field of vision, leaving only A small central field of vision. In glaucoma cases, ganglion cells are damaged, and these cells extend the optic nerve, connecting the retina to the visual processing center on the posterior cortex of the brain.